This information is intended for use by health professionals 1. Name of the medicinal product NeoRecormon IU solution for injection in pre-filled syringe. Qualitative and quantitative composition NeoRecormon IU solution for injection in pre-filled syringe One pre-filled syringe with 0. One ml solution for injection contains IU epoetin beta.
Function[ edit ] Red blood cell production[ edit ] Erythropoietin is an essential hormone for red blood cell production.
Without it, definitive erythropoiesis does not take place. Under hypoxic conditions, the kidney will produce and secrete erythropoietin to increase the production of red blood cells by targeting CFU-Epro erythroblast and basophilic erythroblast subsets in the differentiation.
Erythropoietin has its primary effect on red blood cell progenitors and precursors which are found in the bone marrow in humans by promoting their survival through protecting these cells from apoptosisor cell death.
Erythropoietin is the primary erythropoietic factor that cooperates with various other growth factors e.
The burst-forming unit-erythroid BFU-E cells start erythropoietin receptor expression and are sensitive to erythropoietin. Subsequent stage, the colony-forming unit-erythroid CFU-Eexpresses maximal erythropoietin receptor density and is completely dependent on erythropoietin for further differentiation.
Precursors of red cells, the proerythroblasts and basophilic erythroblasts also express erythropoietin receptor and are therefore affected by it. Nonhematopoietic roles[ edit ] Erythropoietin was reported to have a range of actions beyond stimulation of erythropoiesis including vasoconstriction -dependent hypertensionstimulating angiogenesisand promoting cell survival via activation of EPO receptors resulting in anti-apoptotic effects on ischemic tissues.
However this proposal is controversial with numerous studies showing no effect. Clinical trials in humans with ischemic heart, neural and renal tissues have not demonstrated the same benefits seen in animals. In addition some research studies have shown its neuroprotective effect on diabetic neuropathy, however these data were not confirmed in clinical trials that have been conducted on the deep peroneal, superficial peroneal, tibial and sural nerves.
This results in differentiation, survival and proliferation of the erythroid cell. In controlled experiments, EPO receptor is not detected in those tissues. In the bloodstream, red cells themselves do not express erythropoietin receptor, so cannot respond to EPO.
However, indirect dependence of red cell longevity in the blood on plasma erythropoietin levels has been reported, a process termed neocytolysis. In adults, EPO is synthesized mainly by interstitial cells in the peritubular capillary bed of the renal cortexwith additional amounts being produced in the liver,    and the pericytes in the brain.Many people are concerned about the presence of hormones in milk and other foods, and rightfully so.
Hormones and growth factors (such as IGF-1, insulin-like growth factor-1) are powerful substances with far-ranging effects on virtually all of the body's tissues. Start studying MLT Hematology, Unit 2 ().
Learn vocabulary, terms, and more with flashcards, games, and other study tools. All of the following characteristics of erythropoietin are accurate except A) Glycoprotein hormone B) Can cross the placental barrier between the mother and the fetus.
Erythropoietin is an essential hormone for red blood cell production. Without it, definitive erythropoiesis does not take place.
Under hypoxic conditions, the kidney will produce and secrete erythropoietin to increase the production of red blood cells by targeting CFU-E, pro erythroblast and basophilic erythroblast subsets in the differentiation.
NeoRecormon IU solution for injection in pre-filled syringe. One pre-filled syringe with ml solution for injection contains international units (IU) corresponding to micrograms epoetin beta* (recombinant human erythropoietin). Glycoprotein and glycoprotein are HIV viral coat proteins. Soluble glycoproteins often show a high viscosity, for example, in egg white and blood plasma.
Miraculin, is a glycoprotein extracted from Synsepalum dulcificum a berry which alters human tongue receptors to recognize sour foods as sweet. glycoprotein hormone consisting of amino acids and has a carbohydrate content of 40% of the total erythropoietin molecule (Jelkman, ). Erythropoi-etin has a short half-life in the body, which is h Hariyadi et al.
Characteristics of erythropoietin-alginate microsphere).